The masses varied in size from a pin head an inch or two in diameter.
The cut surfaces the organ, exposed a free incision, best dissertation services owing the variety pathological changes, presented a variegated and striking appearance. The portal vessels small, medium, and in some cases large size, were filled with fresh clots. The homework help thesis statement hepatic vessels, the other hand, were empty. Careful and repeated examination these clots in the fresh state showed them contain pigment writing service reviews masses and cells as a subsequent examination, however, one or two hardened clots in section did not show the presence these cells, possible that their presence was due want sufficient care in preventing a contact the clots with free cells from the neighboring parts. The close apposition large masses pigment cells with the need help with writing a research paper walls the vessels at some points, taken in connection with the above observation, gliggested the idea a perforation the wall a vessel write my essay org at some point, though In sections taken from the more healthy tissue some distance removed from the morbid deposits, where the relation between capillaries and liver cells was still normal, a number cells were seen, resembling abnormally large white blood corpuscles, having a small nucleus and delicate granular protoplasm.
Others same structure, but larger and containing frequently two nuclei, were also found these latter were generally oval or egg-shaped. No pigment The cells from the metastatic deposits examined fresh were mostly large size, and spindle or flask-shaped, containing a large, clear, oval nucleus with well-marked nucleolus.
The melanotic cells contained a coarse granular the best essay writers pigment, which entire the body the cell.
No large pigment masses were found in the cells resembling those described Knapp as altered red blood corpuscles.
The unpigmented cells were crowded with fat granules varying size, and the cells both kinds broke upon the slightest violence, that the nuclei were lying free in the field, and was somewhat difficult indeed obtain buy coursework a An examination in the fresh state the yellowish professional essay writers for hire masses above alluded showed them made an amorphous bris mixed with fat granules, large numbers help writing thesis blood corpuscles, and occasionally liver cells and cells new growth. The red border was due extravasated blood.
Thin sections taken from the neighborhood these masses in the fresh state and after hardening in chromic acid showed their formation due extravasation blood from the portal capillaries.
This was found occur in a zone somewhat removed from the vessel and encircling nearly or entirely, and was well shown where cross sections the vessel were obtained.
The various steps the process, the crowding the capillaries with blood corpuscles, their dilatation and rupture, and the consequent breaking down the liver parenchyma and the formation a mass degenerated tissue, could satisfactorily made out.
In the immediate neighborhood the larger masses these semrcircular or serpentine masses ran together, enclosing a fragment liver tissue. These pec iar appearances seemed, therefore, due a sort necrosis or breaking down the liver tissue, owing an arrest the circulation in these parts, and their shape was caused the anatomical arrangement The bright orange color was probably caused the presence biliary coloring buy custom essay matter. A change similar this was seen in the midst the metastatic need help on my essay deposit A number dilated capillary gall ducts were found at different points, generally several in a cluster, containing casts Sections taken from the melanotic mass after hardening in chromic acid and alcohol showed made cells varying shape, size and arrangement. Their disposition in clusters, the preienoe more than one nucleus, and the varying size, indicated an active cell proliferation. This could best studied at the border, for the line demarcation was not as abrupt as appeared the naked eye, and the morbid growth invaded the neighboring liver tissue for some distance around. The earliest changes that could detected at these points were an accumulation cells new formation in the spaces between the liver cells, the spaces occupied in the normal liver the capillary bloodvessels and lymphatics. At the most peripheral points, these cells were present in numbers sufficient nearly fill these spaces a few them only contained pigment granules. They resembled mostly those found in the capillaries, and described above. The nearer the mass approached, the more numerous these cells become. The spaces are consequently dilated and the liver cells correspondingly compressed.