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Fluoxetine Prozac, the newest antidepressant marketed in the European Union, chemically and pharmacologically distinct from other currently available writers essays tricyclic and secondgeneration paraphrasing a sentence antidepressants. Fluoxetine appears as effective as tricyclic antidepressants with the potential for fewer, but different, side effects.
One difference potential importance the lack weight gain.
In fact weight loss has been reported during therapy for depression. Fluoxetine a bicyclic antidepressant which specifically inhibits the reuptake serotonin and exerts few other direct pharmacological effects. Although most clinically effective antidepressants down-regulate postsynaptic beta-adrenergic receptors, fluoxetine does not appear However, like other antidepressants, fluoxetine does appear cause up-regulation GABA receptors in the frontal lobe Fluoxetine well absorbed from the gastrointestinal tract and absorption not influenced the presence food.Fluoxetine binds extensively plasma proteins, which at least accounts for its large apparent volume distribution.
Elimination fluoxetine extensive metabolism in the liver.
It demethylated hepatically norfluoxetine which also active.
The half-life the parent drug reported one three days, while norfluoxetine has an elimination half-life seven days.
However, the plasma halflife fluoxetine increases with long-term administration, from. days in subjects given day. Only about. fluoxetine excreted unchanged the kidney. The half-life in elderly patients does not appear different from that in younger patients. Clinical trials have shown fluoxetine effective in the treatment depression when compared imipramine, ami From Department Family Medicine, Bowman Gray School triptyline, and doxepin. However, fluoxetine did not appear have increased efficacy over the other agents. Patients with atypical depression Quitkin-Klein criteria and global rating, a help others in need essay longer duration the current depressive episode, history poor response prior treatment, and a history chronic episodic or chronic depression appeared benefit most from fluoxetine. It also interesting that in one fixed-dose study in patients with mild major depression fluoxetine was no more effective that placebo. It appears that the onset action similar other antidepressants, although one study showed the onset action occur within one week. Others have shown the onset occur in Although fluoxetine appears well tolerated in the dosage range daily, one review, patients noted that approximately discontinued therapy due adverse reactions.