Indications and Usage Axid indicated or eight weeks for the treatment active duodenal ulcer in mosl patients, the ulcer will heal within four weeks. Axid IS indicated for maintenance therapy lor duodenal ulcer patients, at a reduced dosage after healing an active duodenal ulcer. The consequences conttnuous therapy with Amd lor longer than one year Contraindication Axtd contraindicaled in patients with known hypersensitivity the drug and should used with caution in patients with hypersensitivity Precautions General Symptomatic response nizatidine therapy does not preclude the presence gastric malignancy Because nizatidine excreted primarily the kidney, dosage should reduced in patients with moderate severe renal msufficienoy Pharmacokinetic studies in patients with hepatorenal syndrome have not been done Part the dose nizatidine metabolized in the liver in patients with normal renal function and uncomplicated hepatic dysfunction, the disposilion nizatidine similar that in normal subiects Laboratory Tests False-positive tests for urobilinogen with Multtslix may occur during therapy with nizatidine cheap essay Drug Inieradions No interactions have been observed between Axid and theophylline, help on essays chlordiazepoxide.
lorazepam, lidocaine. phenytoin, and warlarin. Axid does not inhibit the cytochrome P linked drug-melaboiizing enzyme system, therefore, drug interactions mediated inhibition hepatic metabolism are not expected occur in patients given very high doses, aspirin daily, increases in serum salicylate levels were seen when nizatidine, i, was administered concurrently Carcinogenesis. Mutagenesis, impairment otFertility-A wo-yeit oral carctnogenicity study rals with doses as high as day about limes the recommended daily therapeutic dose showed no evidence a carcinogenic effect There was a dose related increase the density enlerochromattin-like ECL cells in the gastric oxyntic mucosa In a iwo-year study in mice, there was no evidence a carcinogenic effect in male mice, although hyperplastic nodules the liver were increased high dose males compared placebo.
Female nice given the high dose Axid, day, about limes the human dose showed marginally statistically sigmdcant increases in hepatic carcinoma and hepatic nodular hyperplasia with no numerical increase seen in any ihe other dose groups The rale hepatic carcinoma in the high dose animals was within the historical control limits seen for the strain mice used The female mice were given a dose larger than the maximum tolerated dose, as indicated excessive weight decrement compared concurrent controls, and evidence mild liver iniury transaminase elevations. The occurrence a marginal finding at high dose only animals given an excessive, and somewhat hepaloloxic dose, with no evidence a carcinogenic effect in rats, male mice, and female mice given day, about limes Ihe human dose, and a negative mutagenicity battery not considered evidence a carcinogenic potential for buy cheap essay online Axid Axid was not mutagenic in a Oattery tests performed evaluate its potential genetic toxicity, including Oactenal mutation tests, unscheduled DNA synthesis, sister chromatid exchange, and the mouse lymphoma assay In a two-generation, perinatal and postnatal, thesis help services fertility study in rats, doses nizatidine day produced no adverse effects the reproductive performance parental animals or their progeny rabbits at doses times the human dose, revealed no evidence impaired fertility or teratogenic effect, bul, at a dose equivalent times the human dose, treated rabOils had abortions, decreased number live feluses, and depressed essay writing services scams felai weights On intravenous admmislration pregnant New Zealand White rabbils.
mzafidme produced cardiac enlargement, coarctation Ihe aortic arch, and cutaneous edema in one felus mgAg produced ventricular anomaly, distended abdomen, spina bifida, hydrocephaly, and enlarged heart in one fetus There are, however, no adequate and well-controlled studies in pregnant women It also not known whether nizatidine can cause fetal harm when administered a pregnani woman or can affecl reproduction capacity Nizatidine should used during pregnancy only if the potential benefit Nursing WoWers Nizalidme secreted and concentrated in the milk lactaling rals Pups reared treated laclating rals had depressed growth rates. Although pay someone to write paper custom written essays no studies have been conducted lactaling women, nizatidine assumed secreted in human milk, and caution should Cie exercised when nizatidine administered nursing mothers Pediatric Use-Safety and effectiveness children have not been established.
Use in Eiaerly Patients Ulcer healing rales in elderly patienis are similar those in younger age groups The incidence rates adverse events and laboratory lest abnormalities are also similar those seen in olher age groups Age alone may not an important factor ihe disposition nizatidine Elderly patients essay writing help may have reduced renal function Adverse Heectlons Clinical trials nizatidine included almost.
patients given nizatidine in studies varying durations.
Domestic placebo-controlled trials included over, patients given nizatidine and over, given placeOo Among the more common adverse evenls in ihe domestic placebo-controlled irials.
sweating, urticaria, and somnolence.
were significantly more common in Ihe nizatidine group.
A variety less common evenls was also reported was not possible determine whether these were caused nizatidine. Hepadc Hepatocellular injury, evidenced elevated liver eniyme tests The overall rate occurrences elevated liver enzymes and elevations three times the upper limit normal, however, did nol significantly differ from Ihe rate liver enzyme abnormalities In placebo-treated patienis All abnormalities were reversible after discontinuation Cardiovascular clinical pharmacology studies, short episodes asymptomatic ventricular tachycardia occurred in two individuals administered Axid and in three untreated subiects. itfocnne-Clinica pharmacology studies and controlled clinical trials showed no evidence antiandrogenic activity due Axid. Impotence and decreased libido were reported with equal frequency patients who received.Axid and those given placebo Rare reports gynecomastia occurred. Hematologic fzMi thrombocytopenia was reported in a patient who was treated with Axid and anolher Hyreceplor antagonisi On previous occasions, this patient had expenenced Ihrombocytopenia while taking other drugs Integumental-SvieiUnQ and urticaria were reported significantly more frequently in nizatidine than in placebo patients. Flash and exfoliative dermatitis Orfte Hyperuricemia unassociated thesis writing services with gout or nephrolithiasis was Overdosage There little clinical experience with overdosage Axid in humans If overdosage occurs, use activated charcoal, emesis, or lavage should considered along with clinical monitoring and supportive therapy Renal dialysis lor four six hours increased plasma clearance approximately Test animals thai received large doses nizatidine have exhibited cholinergictype effects. Including lacrlmation. salivation, emesis, miosis, and dlarrhea. mproved ejection fraction Improved exercise tolerance a recent double-blind, placebo-controlled study patients with normal sinus rhythm, digoxin prouced a significant increase in ejection fraction ompared captopril.