Fourteen patients had no evidence disease at follow-up times ranging from months after treatment. Of nine patients treated only with brachytherapy, six obtained local control and none these six developed complications.
This result contrasts markedly with patients who received additional external beam radiotherapy, eight whom obtained local control. Of these eight, seven developed pelvic complications requiring surgery.
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The dose decreases as a function the square the distance inverse square law, and the surrounding uninvolved areas receive little additional radiation. Furthermore, a well-recognized phenomenon that tolerance radiotherapy increases as treatment volumes decrease, and treatment volumes are substantially lower with interstitial radiotherapy than with external beam radiotherapy.
We recommend interstitial radiotherapy for selected patients with localized, small-volume, centrally recurrent carcinomas the cervix, even after previous definitive radiotherapy.
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